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Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

Karthikeyan, R and Karthigayan, S and Sri Balasubashini, M and Vijayalakshmi, S and Somasundaram, ST and Balasubramanian, T (2007) Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. International Journal of Cancer Research , 3 (4). pp. 186-190.

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Abstract

The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich’s Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18µg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC – bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

Item Type: Article
Uncontrolled Keywords: Cell line; Ehrlich's ascites carcinoma; sea snake venom
Subjects: Oceanography > marine biology
Divisions: Annamalai Univ - Marine Biology
Depositing User: CASMB
Date Deposited: 08 Mar 2010 04:15
Last Modified: 10 Mar 2010 07:33
URI: http://moeseprints.incois.gov.in/id/eprint/49

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