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Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich’s Ascites Carcinoma xenografted mice

Balasubashini, Sri M and Karthigayan, S and Somasundaram, ST and Balasubramanian, T and Viswanathan, P and Raveendran, P and Menon, Venugopal P (2006) Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich’s Ascites Carcinoma xenografted mice. Bioorganic & Medicinal Chemistry Letters, 16. pp. 6219-6225.

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Abstract

The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich’s ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.

Item Type: Article
Uncontrolled Keywords: Fish venom;PCNA;Tumor metastasis
Subjects: Oceanography > marine biology
Divisions: Annamalai Univ - Marine Biology
Depositing User: CASMB
Date Deposited: 03 Mar 2010 05:56
Last Modified: 03 Mar 2010 05:56
URI: http://moeseprints.incois.gov.in/id/eprint/38

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